Ca2+/Calmodulin dependent protein kinase



Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase (3mfr).

CaMKI – specialized CaM kinase
3nyv – TgCaMK+WHI-P180 – Toxoplasma gondii

3n51 - TgCaMK CBD +RM-1-95

3i7b - TgCaMK CBD+ NM-PP1

3i7c - TgCaMK CBD+ NA-PP2

3ku2 - TgCaMK CBD

3khe, 3i79, 3hzt – TgCaMK

3hx4 – TgCaMK+Ca

3dxn – TgCaMK kinase domain

3mwu – CpCaMK CBD (mutant)+RM-1-95 – Cryptosporidium parvum

3ncg - CpCaMK CBD + NM-PP1

3lij – CpCaMK+Ca

3l19, 3igo, 3hko – CpCaMK

2qg5 – CpCaMK chains A, B, D

3f3z – CpCaMK kinase domain+indirubin_E804

3dfa - CpCaMK kinase domain

2aao – CaMK chains A, B – Arabidopsis thaliana

1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis

1s6j – sCaMK α chain A N-terminal – soybean

1s6i - sCaMK α chain A C-terminal+CaM-like domain

1mxe – rCaMKI CBD+CaM – rat

1ckk – rCaMK CBD chain B+XlCaM

1a06 – rCaMK chain A

CASK – membrane-associated CaMK
3mfr – hCASK CBD – human

3mfs – hCASK+AMPPNP

3mft – hCASK+Mn

3c0g – hCASK kinase domain

3c0h - hCASK kinase domain+AMPPNP

3c0i - hCASK kinase domain+AMP

3mfu - hCASK+AMPPNP+Mn

DAPK – death-associated CaMK
2x0g – hDAPK RD+AD+CaM

2cke – hDAPK+inhibitor

CaMKII – multifunctional CaM kinase
2vz6 - hCaMKII α chains A, B+ indirubin-E804

2zv2 – hCaMKII+STO-609

2wel - hCaMKII δ chain D+CaM

2w2c - hCaMKII δ chain ASD

2vn9 - hCaMKII δ chains A-B

3bhh - hCaMKII β chains A-D

2v7o - hCaMKII γ chain A

2ux0 - hCaMKII γ (mutant) chains A-F

2jam - hCaMKI γ+peptides

2jc6 - hCaMKII δ chains A,C

1hkx - mCaMKII α chains A-N ASD - mouse

3gp2 – cCaMKII δ chain B+CaM – chicken

3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans

3kl8 – CeCaMKII (mutant)+inhibitor

3ksp – CaMKII ASD – Exiguobacterium sibiricum

CaMKIV
2w4o – hCaMKIV+inhibitor